On May 8, 2020, the U.S. Food and Drug Administration (FDA) approved Retevmo (selpercatinib), an oral RET inhibitor developed by Eli Lilly's subsidiary Loxo Oncology.
How much does the Lao Big Bear version of Selpercatinib cost?
The Lao Big Bear version of Selpercatinib is available in a specification of 40mg*120 capsules/box, priced at approximately $280. The specific price may be affected by various factors, and the actual selling price shall prevail.
Indications and approval background of Selpercatinib
On May 8, 2020, the U.S. FDA approved Selpercatinib, an oral RET inhibitor developed by Eli Lilly's subsidiary Loxo Oncology. This drug is primarily indicated for three types of patients: first, adult patients with advanced RET fusion-positive non-small cell lung cancer (NSCLC); second, adult and pediatric patients aged 12 years and older with advanced or metastatic RET-mutant medullary thyroid cancer (MTC) who require systemic therapy; third, adult and pediatric patients aged 12 years and older with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are resistant to radioactive iodine therapy. The emergence of Selpercatinib provides a precise targeted therapy option for patients with RET gene abnormalities, which is particularly significant for cases that respond poorly to conventional treatments. Genetic testing is required to confirm RET fusion or mutation status before use, but no FDA-approved companion diagnostic test is currently available.
Recommended dosage and important administration instructions for Selpercatinib
The recommended dosage of Selpercatinib is based on body weight: 120 mg orally for patients weighing less than 50 kg, and 160 mg for those weighing 50 kg or more. Take twice daily, approximately every 12 hours, until disease progression or unacceptable toxicity occurs. Capsules should be swallowed whole, not crushed or chewed. If vomiting occurs after taking the dose, do not take a replacement dose; take the next dose at the scheduled time. If more than 6 hours remain before the next scheduled dose, the missed dose should not be taken. Selpercatinib can be taken with or without food, but when co-administered with a proton pump inhibitor (PPI), it must be taken with food. Strictly follow medical advice during treatment; do not adjust the dose or stop taking the drug on your own.
