Certain medications should not be used concomitantly due to safety risks. Some drugs may alter the blood concentrations of other medications you take, potentially increasing side effects or reducing therapeutic efficacy.
Selpercatinib may cause serious cardiac adverse reactions. Your risk may be elevated if you are also taking certain medications for infections, asthma, cardiac disorders, hypertension, depression, psychiatric conditions, cancer, malaria, or HIV.
Some medications can significantly reduce the effectiveness of selpercatinib if taken together. If you use any of the following, separate their administration from your selpercatinib dose:
Antacids containing aluminum, magnesium, calcium, simethicone, or buffered formulations: take selpercatinib at least 2 hours before or 2 hours after the antacid.
Gastric acid–reducing agents (such as cimetidine, famotidine, nizatidine, and others): take selpercatinib at least 2 hours before or 10 hours after these medications.
Numerous medications may interact with selpercatinib, including prescription and over‑the‑counter drugs, vitamins, and herbal supplements. Not all potential interactions are listed here. Inform your doctor of all medications you are currently using.
