Onset Time of Ixazomib

After oral administration, ixazomib reaches peak plasma concentration in approximately 1 hour, but it takes about 9.5 days to be completely metabolized and eliminated. With a once-weekly dosing schedule, the total drug accumulation in the body will reach approximately twice the initial level by day 15. Currently, there is no definitive authoritative research data on the specific onset time and duration of efficacy.