Anagrelide is primarily used to treat thrombocytosis, especially essential thrombocytosis, reducing the risk of thrombosis and improving patients' quality of life and survival.
Anagrelide Side Effects Requiring Immediate Medical Attention
If any of the following side effects occur while taking Anagrelide, consult your doctor immediately:
1. Common Side Effects of Anagrelide
(1) Swelling of the face, arms, hands, lower legs, or feet; body aches; burning, tingling, itching, numbness, tingling; chest pain; congestion; cough; difficulty or labored breathing; dry or sore throat;
(2) Rapid, irregular, severe, or rapid heartbeat or pulse; fever; hoarseness; rapid weight gain; runny nose; swelling and tenderness of glands in the neck; chest tightness; difficulty swallowing; voice changes.
2. Less common side effects of Anagrelide:
(1) Anxiety, blurred vision, burning sensation during urination, chills, cold sweats, confusion, decreased urine output, dehydration, difficulty or pain during urination, jugular vein dilation, dizziness, fainting, or lightheadedness when suddenly standing up from a lying or sitting position;
(2) Extreme fatigue or weakness, general malaise or illness, headache, irregular breathing, joint pain, large flat blue or purple patches on the skin, loss of appetite, muscle pain, nausea, noisy breathing;
(3) Pale skin, redness of the face, neck, and arms, occasionally redness of the upper chest, severe pain or pressure in the chest, jaw, neck, back, or arms, sudden severe headache or weakness, swollen, painful, or tender lymph nodes in the neck, armpits, or groin;
(4) Insomnia, difficulty breathing during exercise, abnormal bleeding or bruising, unusual fatigue or weakness, vomiting, bloody or coffee-ground-like vomit, weight gain. 3. Rare Side Effects of Anagrelide
Clay-colored stools, dark urine, loss of appetite, dry cough, general fatigue or weakness, shortness of breath, skin rash or itching, stomach pain or tenderness, yellow eyes or skin.
Mild Side Effects of Anagrelide
If you experience any of the following side effects while taking Anagrelide, or have any questions about these side effects, please consult a healthcare professional:
1. Common Side Effects of Anagrelide
Back pain, belching, diarrhea, excessive gas in the stomach or intestines, feeling full, heartburn, hives, indigestion, lack of energy or weakness, pain, flatulence, stomach upset, discomfort or pain.
2. Uncommon Side Effects of Anagrelide
(1) Burning sensation in the chest or stomach, vision changes, constipation, persistent tinnitus, buzzing, or other unexplained noises in the ears, depression, difficulty moving, double vision, hair loss or thinning, hearing loss, impaired vision
(2) Increased skin sensitivity to sunlight, leg cramps, memory loss, muscle pain or stiffness, memory problems, skin redness or other discoloration, double vision, severe sunburn, drowsiness or unusual sleepiness, nasal congestion, swelling or inflammation of the mouth, joint swelling.
Side Effects of Anagrelide for Healthcare Professionals
1. Common Adverse Reactions of Anagrelide
Very common (incidence 10% or more): Edema (20.6%).
Common (incidence 1%-10%): Peripheral edema.
Unknown incidence: Tinnitus, flu-like symptoms, chills.
2. Cardiovascular System
Very common (incidence 10% or higher): Palpitation (26.1%).
Common (incidence 1%-10%): Chest pain, tachycardia.
Incidence unknown: Arrhythmia, cardiovascular disease, angina, heart failure, orthostatic hypotension, thrombosis, vasodilation.
Post-marketing reports of Anagrelide: Torsades de pointes, ventricular tachycardia, variant angina.
3. Gastrointestinal System
Very common (incidence 10% or higher): Diarrhea (25.7%), nausea (17.1%), abdominal pain (16.4%), flatulence (10.2%).
Common (incidence 1%-10%): Vomiting, loss of appetite, indigestion, constipation, gastritis, aphthous stomatitis, pharyngitis, bleeding, belching, dehydration.
4. Nervous System
Very common (incidence 10% or higher): Headache (43.5%), fatigue (23.1%), dizziness (15.4%), pain (15%).
Common (incidence 1%-10%): Fever.
Unknown incidence: Migraine, syncope, drowsiness, confusion, insomnia, nervousness, amnesia.
5. Hematologic System
Unknown incidence: Anemia, thrombocytopenia, ecchymosis, lymphadenopathy.
6. Liver
Very rare (incidence less than 0.01%): Cholestatic liver failure.
Unknown incidence: Elevated liver enzymes.
7. Musculoskeletal System
Common (incidence 1%-10%): Back pain.
Unknown incidence: Arthralgia, myalgia, leg cramps.
8. Respiratory System
Very common (incidence 10% or higher): Dyspnea (11.9%).
9. Skin
Common (1%-10% incidence): Rash (including urticaria).
Unknown incidence: Skin diseases, hair loss, pruritus.
10. Eyes
Unknown incidence: Photosensitivity, amblyopia, visual disturbances, visual field abnormalities, diplopia.
11. Genitourinary System
Unknown incidence: Dysuria, hematuria.
12. Allergic Reactions
Unknown incidence: Severe allergic pneumonia.
13. Kidneys
Post-marketing report of Anagrelide: Tubulointerstitial nephritis.
14. Mental Health
Unknown incidence: Depression.
