Price of Alectinib per Box
Alectinib is a targeted drug for ALK-positive metastatic non-small cell lung cancer, developed by Roche (Switzerland) and approved by the U.S. FDA in 2015.Prices vary by manufacturer, dosage form, and region. The Lao Da Xiong version of alectinib is 150 mg * 112 capsules, approximately 332 US dollars per box. Actual price depends on local medical insurance policies and hospital pricing; the above is for reference only.
Where to Purchase Alectinib
Hospitals and Pharmacies
Alectinib is approved and covered by medical insurance in China. Patients may purchase it with a prescription at hospitals or large pharmacies, ensuring reliable quality for originator brands or insurance-covered products.
Cross-Border E-Commerce Platforms
Patients seeking generic versions may use legitimate cross-border e-commerce platforms partnered with overseas pharmaceutical companies. Verify manufacturer, batch number, and expiration date to avoid counterfeit or substandard products.
General Precautions
Choose reputable channels, inspect intact packaging and clear labeling. Consult a doctor or pharmacist with questions to ensure safe use.
Pharmacokinetics of Alectinib
Absorption and Distribution
Following oral administration with food, peak plasma concentration is reached at approximately 4 hours. Food increases bioavailability, so administration with food is recommended. Alectinib distributes widely and effectively penetrates tumor tissue.
Metabolism and Excretion
Alectinib is mainly metabolized by the liver to form the active metabolite M4. Dose adjustment is required in patients with severe hepatic impairment to prevent accumulation. The drug and its metabolites are primarily excreted in feces, with a small amount eliminated in urine.
Use in Special Populations
Dose adjustment may be needed in patients with hepatic or renal impairment based on individual condition. Pharmacokinetics are similar in elderly and young adult patients, but close monitoring is still advised.
