Use of Sotorasib may cause a range of side effects, some of which are serious and require prompt medical attention. During treatment with Sotorasib, carefully read the package insert, follow your physician's instructions, and familiarize yourself with basic side effect information for timely management.
Serious Side Effects of Sotorasib
In addition to the expected therapeutic effects, Sotorasib may cause some adverse reactions. Side effects and adverse reactions to Sotorasib vary from person to person; if any occur, please consult your doctor or seek medical attention promptly.
Side Effects Requiring Immediate Medical Attention
Chest pain or tightness, cough, darkening of urine color, fever or chills, light-colored stools, loss of appetite, nausea or vomiting, sneezing, sore throat, stomach pain, difficulty breathing, unusual tiredness or weakness, yellowing of the eyes or skin.
Side Effects Usually Not Requiring Medical Intervention
These side effects may resolve on their own as treatment progresses, or may be improved through preventive/relief measures. If symptoms persist or are bothersome, please consult a healthcare professional.
Blistering, crusting, irritation, itching, or redness of the skin; constipation; dry, flaking skin; diarrhea; difficulty with movement; joint or bone pain; weakness or lack of energy; muscle aches, cramps, pain, or stiffness; flat or raised rash on the skin; swelling of the hands, ankles, feet, or lower legs; swelling of the testicles.
Common Side Effects of Sotorasib
The most common side effects of Sotorasib include diarrhea, musculoskeletal pain, nausea, fatigue, hepatotoxicity, and cough; the most common laboratory abnormalities with Sotorasib include lymphopenia, decreased hemoglobin, elevated AST, elevated ALT, decreased blood calcium, elevated alkaline phosphatase, increased urine protein, and decreased blood sodium.
Serious adverse reactions to Sotorasib: serious adverse reactions occurred in 50% of patients, including pneumonitis, hepatotoxicity, and diarrhea; the most common Grade 3 or higher serious adverse reactions were elevated ALT, elevated AST, and diarrhea.
Fatal adverse reactions to Sotorasib: included respiratory failure, pneumonitis, cardiac arrest, heart failure, gastric ulcer, and pneumonia.
