Crizotinib has different specific usages in adults and children for different indications. Users are advised to consult their doctor before using crizotinib to fully understand the medication.
Used Adult Dosage
Non-Small Cell Lung Cancer
Dosage: Oral, 250 mg twice daily;
Duration of Treatment: Until disease progression or unacceptable toxicity occurs.
Anaplastic Large Cell Lymphoma (ALK-positive)
Adolescent Adult Dosage: Oral, 280 mg/m² twice daily.
Duration of Treatment: Until disease progression or unacceptable toxicity occurs.
Recommended Dosage Based on Body Surface Area (BSA):
BSA 0.6–0.8 m²: Oral, 200 mg twice daily;
BSA 0.81–1.16 m²: Oral, 250 mg twice daily;
BSA 1.17–1.51 m²: Oral, 400 mg twice daily;
BSA 1.52–1.69 m²: Oral, 450 mg twice daily;
BSA at least 1.7 m²: Oral, 500 mg twice daily.
Inflammatory Myofibroblastoma
Dosage: Oral, 250 mg twice daily.
Duration of Treatment: Until disease progression or unacceptable toxicity.
Used Dosage in Children
Inflammatory Myofibroblastoma
Applicable Age: 1 year and older.
Dosage: Oral, 280 mg/m² twice daily.
Duration of Treatment: Until disease progression or unacceptable toxicity.
Recommended dosage based on body surface area (BSA):
BSA 0.6–0.8 m²: Oral, 200 mg twice daily;
BSA 0.81–1.16 m²: Oral, 250 mg twice daily;
BSA 1.17–1.51 m²: Oral, 400 mg twice daily;
BSA 1.52–1.69 m²: Oral, 450 mg twice daily;
BSA at least 1.7 m²: Oral, 500 mg twice daily.
Anaplastic large cell lymphoma (ALK-positive)
Applicable age: 1 year and older.
Dosage: Oral, 280 mg/m² twice daily.
Duration of treatment: Until disease progression or unacceptable toxicity.
Recommended dosage based on body surface area (BSA):
BSA 0.6-0.8 m²: Oral administration, 200 mg twice daily;
BSA 0.81-1.16 m²: Oral administration, 250 mg twice daily;
BSA 1.17-1.51 m²: Oral administration, 400 mg twice daily;
BSA 1.52-1.69 m²: Oral administration, 450 mg twice daily;
BSA at least 1.7 m²: Oral administration, 500 mg twice daily.
The full dosage and administration information for this drug is extensive; it is recommended that you read the complete package insert for Crizotinib.
