Tazemetostat dosage is typically 800 mg twice daily. The specific dosage of Tazemetostat should be strictly followed per physician's instructions; do not self-medicate.
Tazemetostat Usual Adult Dosage
1. Soft Tissue Sarcoma
(1) Applicable Population
For adult patients with metastatic or locally advanced epithelioid sarcoma that is not amenable to complete resection.
(2) Recommended Dosage
800 mg twice daily. Continue until disease progression or unacceptable toxicity.
2. Follicular Lymphoma
(1) Applicable Population
For patients with relapsed/refractory follicular lymphoma (R/R FL) who have received ≥2 prior systemic therapies and whose tumors are confirmed to harbor EZH2 gene mutations, or for those in this specific population who lack better treatment options.
(2) Recommended Dosage
800 mg twice daily. Continue until disease progression or unacceptable toxicity.
Tazemetostat Pediatric Dosage (Aged 16 and Above)
1. Soft Tissue Sarcoma
(1) Applicable Population
For adult patients with metastatic or locally advanced epithelioid sarcoma that is not amenable to complete resection.
(2) Recommended Dosage
800 mg twice daily. Continue until disease progression or unacceptable toxicity.
2. Age Restriction Notes
(1) Epithelioid sarcoma indication: Safety and efficacy have not been established in patients under 16 years of age.
(2) Follicular lymphoma indication: Safety and efficacy have not been established in patients under 18 years of age.
Tazemetostat Administration Precautions
1. Administration Method
May be taken with or without food. Swallow tablets whole; do not break, crush, or chew.
2. Missed Dose
Do not make up for the missed dose; take the next dose at the scheduled time.
3. Vomiting After Dosing
Do not make up for the dose; take the next dose at the scheduled time.
