What are the adverse reactions of gefitinib fumarate tablets?
Common reactions include: abnormal liver function (elevated ALT/AST), anemia, thrombocytopenia, fever with neutropenia, diarrhea, nausea, fatigue, and weakness. If these adverse reactions occur, you should contact your doctor promptly to assess whether medication adjustments are necessary.
Severe reactions require special attention:
1. Differentiation syndrome: Symptoms include fever, difficulty breathing, sudden weight gain, and edema; in severe cases, it can be life-threatening. Immediate hospitalization is required in this situation.
2. Reversible posterior encephalopathy (PRES): A rare neurological problem that may cause symptoms such as seizures, headaches, confusion, and visual disturbances. If these symptoms occur, stop taking the medication immediately and seek medical attention promptly.
3. Prolonged QT interval on electrocardiogram: This can be detected through regular electrocardiogram examinations, and a doctor needs to assess whether the dosage needs to be adjusted.
4. Pancreatitis: Although the direct link between the drug and pancreatitis is not yet clear, if symptoms such as severe upper abdominal pain, nausea and vomiting occur, you should seek medical attention immediately and stop taking the drug as prescribed by your doctor.
Under what circumstances should gefitinib fumarate tablets be discontinued immediately?
Medication should be discontinued in the following situations:
Differentiation syndrome showed no improvement after 48 hours of hormone therapy;
Symptoms associated with reversible posterior encephalopathy appeared;
Other serious adverse reactions require discontinuation of the medication upon evaluation by a physician.
In what situations should you go to the hospital as soon as possible?
Seek immediate medical attention if any of the following conditions occur:
Severe adverse reaction symptoms worsened;
Sudden allergic reaction: symptoms such as large welts on the skin, difficulty breathing, and swelling of the face or throat may be life-threatening and require emergency treatment.
